AUTHOR=Zhao Jiayu , Li Mei , Xu Jiao , Cheng Wei 

TITLE=The modulation of ion channels in cancer chemo-resistance

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.945896

DOI=10.3389/fonc.2022.945896

ISSN=2234-943X

ABSTRACT=<p>Ion channels modulate the flow of ions into and out of a cell or intracellular organelle, leading to generation of electrical or chemical signals and regulating ion homeostasis. The abundance of ion channels in the plasma and intracellular membranes are subject to physiological and pathological regulations. Abnormal and dysregulated expressions of many ion channels are found to be linked to cancer and cancer chemo-resistance. Here, we will summarize ion channels distribution in multiple tumors. And the involvement of ion channels in cancer chemo-resistance will be highlighted.</p>