AUTHOR=Cao Jun , Yu Yaner , Zhou Yangkun , Ji Qing , Qian Wenkang , Jia Dongdong , Jin Gu , Qi Yajun , Li Xin , Li Ningning , Li Tao , Fang Meiyu , Jin Hongchuan 

TITLE=Case report: complete remission with crizotinib in ROS1 fusion-positive sinonasal mucosal melanoma

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.942258

DOI=10.3389/fonc.2022.942258

ISSN=2234-943X

ABSTRACT=<sec><title>Introduction</title><p>Sinonasal mucosal melanoma (SNMM) originates from melanocytes. Currently, the main treatment methods, including surgery, radiotherapy and chemotherapy, have little effect on the recurrence and metastasis of SNMM. However, targeted therapy may be a breakthrough in treating SNMM.</p></sec><sec><title>Methods</title><p>A SNMM patient with ROS1 fusion received 250mg Crizotinib capsule (2 times a day, 1 tablet each time) therapy.</p></sec><sec><title>Results</title><p>The patient achieved partial remission after 4 months of treatment and complete remission after 8 months of treatment.</p></sec><sec><title>Conclusion</title><p>Our findings suggest that crizotinib can be an option to improve overall survival and quality of life of patients with metastatic ROS1-fusion SNMM. We believe that our report will provide insights for the application of crizotini in the treatment of melanoma.</p></sec>