AUTHOR=Zou Yuheng , Zhang Hongying , Bi Feng , Tang Qiulin , Xu Huanji 

TITLE=Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.938502

DOI=10.3389/fonc.2022.938502

ISSN=2234-943X

ABSTRACT=<p>Cholesterol metabolism is often dysregulated in cancer. Squalene monooxygenase (SQLE) is the second rate-limiting enzyme involved in cholesterol synthesis. Since the discovery of SQLE dysregulation in cancer, compelling evidence has indicated that SQLE plays a vital role in cancer initiation and progression and is a promising therapeutic target for cancer treatment. In this review, we provide an overview of the role and regulation of SQLE in cancer and summarize the updates of antitumor therapy targeting SQLE.</p>