AUTHOR=Abravan Azadeh , Price Gareth , Banfill Kathryn , Marchant Tom , Craddock Matthew , Wood Joe , Aznar Marianne C. , McWilliam Alan , van Herk Marcel , Faivre-Finn Corinne TITLE=Role of Real-World Data in Assessing Cardiac Toxicity After Lung Cancer Radiotherapy JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.934369 DOI=10.3389/fonc.2022.934369 ISSN=2234-943X ABSTRACT=

Radiation-induced heart disease (RIHD) is a recent concern in patients with lung cancer after being treated with radiotherapy. Most of information we have in the field of cardiac toxicity comes from studies utilizing real-world data (RWD) as randomized controlled trials (RCTs) are generally not practical in this field. This article is a narrative review of the literature using RWD to study RIHD in patients with lung cancer following radiotherapy, summarizing heart dosimetric factors associated with outcome, strength, and limitations of the RWD studies, and how RWD can be used to assess a change to cardiac dose constraints.