AUTHOR=Ye Chen , Wei Wei , Tang Xuebin , Li Feng , Xin Baoquan , Chen Qianqian , Wei Haifeng , He Shaohui , Xiao Jianru TITLE=Sacral Ewing sarcoma with rib, lung, and multifocal skull metastases: A rare case report and review of treatments JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.933579 DOI=10.3389/fonc.2022.933579 ISSN=2234-943X ABSTRACT=

Ewing sarcoma (ES) rarely derives from the sacrum or mobile spine. The discovery of primary ES with multimetastatic involvements is exceedingly less frequent in clinical practice. A 23-year-old man with initial primary sacral ES developed metastases of rib, lung, and multifocal skull after receiving surgical intervention and series of adjuvant therapies. We provide this very rare case consisting of its clinical features, imaging findings, treatments, and outcomes. Therapeutic modalities of ES are also reviewed in previous published articles. The prognosis of metastatic ES remains dismal; effective therapeutic modalities for ES require multidisciplinary collaboration, with more high-quality clinical trials to promote the optimal protocols.