AUTHOR=Cheng Xin , Lou Kecheng , Ding Liang , Zou Xiaofeng , Huang Ruohui , Xu Gang , Zou Junrong , Zhang Guoxi 

TITLE=Clinical potential of the Hippo-YAP pathway in bladder cancer

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.925278

DOI=10.3389/fonc.2022.925278

ISSN=2234-943X

ABSTRACT=Bladder cancer (BC) is one of the world's most frequent cancers. Surgery coupled with adjuvant platinum-based chemotherapy is the current standard of therapy for BC. However, the proportion of patients still has the progressive disease after treatment, which tends to chemotherapy resistance, and has a poor prognosis. As a result, identifying novel treatment targets is critical. The hippo-YAP pathway is a crucial regulator of stem cells and cancer cells, which is linked to the incidence and progression of a variety of cancers. Here, we summarize the evidence that some dysregulation of the Hippo-YAP pathways induced the occurrence, recurrence, progression, and chemotherapy resistance of BC, and emphasize the role of the Hippo-YAP pathway in regulating bladder cancer stem-like cells (BCSCs). Finally, we prospect Hippo-YAP as a potential therapeutic target for BC.