AUTHOR=Chen Can , Wang Runlu , Chen Xi , Hou Yulong , Jiang Jingting TITLE=Targeting CD47 as a Novel Immunotherapy for Breast Cancer JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.924740 DOI=10.3389/fonc.2022.924740 ISSN=2234-943X ABSTRACT=

Nowadays, breast cancer has become the most common cancer worldwide with a high mortality rate. Immune checkpoint blockade holds great promise in tumor‐targeted therapy, and CD47 blockade as one immune therapy is undergoing various preclinical studies and clinical trials to demonstrate its safety and efficacy in breast cancer. In this review, we summarized different therapeutic mechanisms targeting CD47 and its prognostic role and therapeutic value in breast cancer.