AUTHOR=Seyedin Steven N. , Bassalow Rostem , Mawlawi Osama R. , Turner Lehendrick M. , Patel Roshal R. , Mazin Samuel R. , Oderinde Oluwaseyi M. , Voronenko Yevgen , Wages Cody A. , Olcott Peter D. , Chang Joe Y. , Balter Peter A. , Welsh James W. 

TITLE=The potential of biology-guided radiation therapy in thoracic cancer: A preliminary treatment planning study

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.921473

DOI=10.3389/fonc.2022.921473

ISSN=2234-943X

ABSTRACT=<sec><title>Purpose</title><p>We investigated the feasibility of biology-guided radiotherapy (BgRT), a technique that utilizes real-time positron emission imaging to minimize tumor motion uncertainties, to spare nearby organs at risk.</p></sec><sec><title>Methods</title><p>Volumetric modulated arc therapy (VMAT), intensity-modulated proton (IMPT) therapy, and BgRT plans were created for a paratracheal node recurrence (case 1; 60 Gy in 10 fractions) and a primary peripheral left upper lobe adenocarcinoma (case 2; 50 Gy in four fractions).</p></sec><sec><title>Results</title><p>For case 1, BgRT produced lower bronchus V40 values compared to VMAT and IMPT. For case 2, total lung V20 was lower in the BgRT case compared to VMAT and IMPT.</p></sec><sec><title>Conclusions</title><p>BgRT has the potential to reduce the radiation dose to proximal critical structures but requires further detailed investigation.</p></sec>