AUTHOR=Lu Mengyang , Zhou Yuanshuai , Sun Linjuan , Shafi Shaheryar , Ahmad Nafees , Sun Minxuan , Dong Jun 

TITLE=The molecular mechanisms of ferroptosis and its role in glioma progression and treatment

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.917537

DOI=10.3389/fonc.2022.917537

ISSN=2234-943X

ABSTRACT=<p>Ferroptosis is one of the programmed modes of cell death that has attracted widespread attention recently and is capable of influencing the developmental course and prognosis of many tumors. Glioma is one of the most common primary tumors of the central nervous system, but effective treatment options are very limited. Ferroptosis plays a critical role in the glioma progression, affecting tumor cell proliferation, angiogenesis, tumor necrosis, and shaping the immune-resistant tumor microenvironment. Inducing ferroptosis has emerged as an attractive strategy for glioma. In this paper, we review ferroptosis-related researches on glioma progression and treatment.</p>