AUTHOR=Butler Miriam , Vervoort Britt M.T. , van Ingen Schenau Dorette S. , Jongeneel Lieneke , van der Zwet Jordy C.G. , Marke René , Meijerink Jules P.P. , Scheijen Blanca , van der Meer Laurens T. , van Leeuwen Frank N. TITLE=Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.905665 DOI=10.3389/fonc.2022.905665 ISSN=2234-943X ABSTRACT=
Although long-term survival in pediatric acute lymphoblastic leukemia (ALL) currently exceeds 90%, some subgroups, defined by specific genomic aberrations, respond poorly to treatment. We previously reported that leukemias harboring deletions or mutations affecting the B-cell transcription factor