AUTHOR=Xie Zhenliang , Li Jincheng , Huang Pu , Zhang Ye , Yang Jingkuan , Liu Kangdong , Jiang Yanan 

TITLE=Applications and Achievements of Single-Cell Sequencing in Gastrointestinal Cancer

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.905571

DOI=10.3389/fonc.2022.905571

ISSN=2234-943X

ABSTRACT=<p>Gastrointestinal cancer represents a public health concern that seriously endangers human health. The emerging single-cell sequencing (SCS) technologies are different from the large-scale sequencing technologies which provide inaccurate data. SCS is a powerful tool for deciphering the single-cell resolutions of cellular and molecular landscapes, revealing the features of single-cell genomes, transcriptomes, and epigenomes. Recently, SCS has been applied in the field of gastrointestinal cancer research for clarifying the origin and heterogeneity of gastrointestinal cancer, acquiring micro-environmental information, and improving diagnostic and treatment methods. This review outlines the applications of SCS in gastrointestinal cancer research and summarizes the most recent advances in the field.</p>