Yan-Li Wang
Yuan Zhang1
Jun Xu- 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- 2China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Chimeric antigen receptor-T (CAR-T) cell therapy is a breakthrough for B-cell hematological malignancies but is commonly associated with cytokine release syndrome and neurotoxicity and is occasionally complicated by neurological symptoms, such as cognitive disturbances. Currently, no effective treatments for CAR-T therapy-related cognitive impairment are available. Here, we present a 22-year-old patient with cognitive impairment who was treated with CAR-T cells as a salvage therapy for Burkitt lymphoma. One month after CAR-T cell infusion, he experienced memory loss that mainly manifested as forgetting recent-onset events. Two months of rehabilitation and hyperbaric oxygen therapy failed to provide clinical improvement. Subsequently, the patient improved with oral oxiracetam for 5 months. However, after 10 months of withdrawal, he showed significantly worse memory decline. Then, he began to take sodium oligomannate (22 February 2021). Follow-up testing at 6 and 12 months revealed maintenance of memory gains with sodium oligomannate alone or in combination with rivastigmine. Our case shows that CAR-T therapy may compromise cognitive function and that sodium oligomannate may have partial efficacy in restoring cognitive performance and activities of daily living. This may provide insights for further applications of sodium oligomannate for neurological symptoms, especially cognitive deficits following CAR-T cell therapy.
Introduction
Burkitt lymphoma is a rare and highly aggressive B-cell neoplasm but is generally curable when treated with brief-duration, high-intensity chemotherapeutic regimens. However, some patients develop recurrence or fail to respond. Chimeric antigen receptor-T (CAR-T) cell therapy is an important innovative approach to treating hematological and other malignancies. However, cognitive impairment is an important symptom of neurotoxicity that is associated with a poor prognosis of CAR-T cell infusion (1). Currently, there is no effective intervention method, and this is the first case describing sodium oligomannate to control the progression of cognitive impairment after CAR-T cell therapy.
Case report
A 22-year-old man was admitted to the Cognitive Disorders Department of our hospital in February 2021 complaining of gradual memory deterioration for more than 1 year.
The patient underwent CAR-T immunotherapy (specific treatment options not available) for Burkitt lymphoma in March 2019, and 1 month postoperatively, he first developed memory loss, with the main cognitive symptom being a failure to remember recent events. The patient suffered a grand mal seizure in April 2019, which was followed by a significant worsening of cognitive impairment, manifested by not recognizing familiar people, such as his parents, and not recognizing common objects, such as birds in paintings. MMSE and MoCA scores before treatment are unavailable. From June to August 2019, the patient was treated with rehabilitation and hyperbaric oxygen in our hospital with no significant improvement in cognitive symptoms. Since October 2019, the patient was administered oxiracetam 0.8 g orally twice daily for 5 months. The patient’s memory deterioration has improved, and he began to gradually recognize his parents and primary school and high school classmates and he can recall simple mobile phone passwords. However, the patient discontinued his medication due to the impact of COVID-19, and at month 15, he showed significantly worse memory decline, which primarily manifested as forgetting where to put things, emotional instability, and impaired daily living activities.
The study was approved by the Institutional Review Board of Beijing Tiantan Hospital of Capital Medical University (KY-2021-028-01). Informed consent was signed by the patient and his father. A timeline of the historical and current information is shown in Figure 1. Since February 2021, when the patient was seen in our outpatient clinic, the patient has been taking regular oral doses of sodium oligomannate (GV-971) 450 mg twice daily without any other medication. There were significant improvements in the overall condition of the patient, including improvements in the activities of daily living, more stable emotions, and increased MMSE and MoCA.
Figure 1 Medical history of the patient.
To further improve his cognition, the patient has been co-administering rivastigmine hydrogen tartrate capsules 3 mg twice daily since August 2021; in January 2022, the regimen of 3 mg capsules twice daily was substituted with a 9.5-mg transdermal patch once daily. These were the only medications that the patient received. In comparison to sodium oligomannate alone, the patient was stable with no significant cognitive improvement. The results of the patient’s three neuropsychological examinations are shown in Table 1. The results for 14 cytokines and CAR-T cell copy numbers in peripheral blood samples from August 2021 are shown in eTables 1, 2. Figure 2 shows the comparison of cerebral perfusion findings with 3D arterial spin labeling (ASL) imaging before and after treatment with sodium oligomannate. Significantly, the hypoperfusion regions around the lesion improved following GV-971 treatment, and cerebral perfusion was stable during combination therapy with rivastigmine. Furthermore, Table 2 shows cerebral blood flow (CBF) assessed with ASL in cognitive regions. The patient’s condition has improved steadily since the follow-up, with occasional fluctuations in symptoms. The patient’s cranial MRI in August 2021 showed that abnormal signals were present in the bilateral insula, hippocampus, amygdala, subcallosal gyrus, left temporal lobe, anterior cingulate, and splenium cingulate, which were not markedly changed from 6 months before. In addition, a neurological examination revealed poor memory and executive function, without other obvious abnormalities.
Table 1 Neurophysiological follow-up.
Figure 2 ASL-MRI on 9 February 2021 before GV-971 treatment (A), 29 July 2021 (B), and 18 January 2022 (C). After treatment with GV-971 (B, C), regions of low perfusion in green were visibly decreased.
Table 2 Cerebral blood flow follow-up.
Discussion
After choosing to stop taking oxiracetam for 10 months, his MMSE score was 23 and his MoCA score was 21. After 6 months on sodium oligomannate, the patient improved significantly, with MMSE scores ranging from 23 to 26 and MoCA scores ranging from 21 to 23. The combination of sodium oligomannate with rivastigmine did not show significant cognitive improvement, but the effects were stable. Currently, the patient has a normal digital memory, can basically take care of himself, can use computers and other tools, and can interact with people around him in a normal way.
CAR-T cell therapy as a treatment for Burkitt lymphoma is a nascent, burgeoning field. Consistent with our observations, a previous study also indicated cognitive difficulties following CAR-T cell therapy (2). The specific mechanism may involve several factors, such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) (3). CRS typically occurs in the first week after CAR T-cell infusion and ICANS in the second week after infusion, usually following the peak of CRS severity and lasting 5 to 10 days (4). Mild ICANS (grades 1 and 2) is characteristic of aphasia, confusion, and impaired fine motor skills, and seizures, cerebral edema, and coma can manifest in severe cases (grades 3 and 4) (4). Both symptomatic treatment and supportive care are recommended to treat mild ICANS, whereas corticosteroids are the primary treatment strategy for severe ICANS (5, 6). Earlier administration of steroids could prevent severe effects without reducing CAR-T therapy efficacy (7). The severity of CRS is strongly correlated with the severity of ICANS, and approaches to CRS mitigation may subsequently reduce the risk of ICANS (8). Although tocilizumab has no effect on most ICANS, it is highly effective in the management of CRS (5, 9).
Although associations of early neurotoxicity with cognitive decline are significant, a large-scale cohort of patients receiving CAR-T cell therapy is needed to detect a correlation between acute neurotoxicity and long-term cognitive difficulties (2). There is also a study that found no cognitive toxicity of CAR-T cell treatment (10). The prevalence of cognitive difficulty following CAR-T cell therapy is higher among white individuals than among non-white patients, and a possible explanation for the discrepancies may arise from cultural differences (2).
A phase 3 clinical trial of sodium oligomannate demonstrated that GV-971 could effectively improve cognitive deficits in mild-to-moderate Alzheimer’s dementia (11).
Sodium oligomannate could reduce the concentration of phenylalanine and alleviate Th1-related neuroinflammation and cognitive decline by effectively modulating the gut microbiota (12). It may play an important role in preserving dendritic spines and synaptic plasticity (13). In addition, it can also directly inhibit the formation of Aβ fibrils and decrease Aβ deposition in the brain (14, 15). There are no studies that have evaluated the relationship between GV-971 and CBF, and the mechanism of GV-971 in cerebrovascular disease has not been explored. Patients with encephalitis and Alzheimer’s disease may exhibit regional CBF abnormalities, and CBF is a sensitive biomarker for the assessment of neuroinflammation and drug efficacy (16). This case strongly suggested that GV-971 might improve cognitive function by increasing cerebral blood flow.
Conclusion
These results indicated that sodium oligomannate exerts its protective effect on cognitive improvement following CAR-T cell therapy through the inhibition of neuroinflammation and an increase in cerebral perfusion. Importantly, a larger cohort is needed to verify the results.
Data availability statement
The original contributions presented in the study are included in the article/Supplementary Material. Further inquiries can be directed to the corresponding author.
Ethics statement
This study was reviewed and approved by Institutional Review Board of Beijing Tiantan Hospital of Capital Medical University (KY-2021-028-01). The patients/participants provided their written informed consent to participate in this study.
Author contributions
All authors have made a substantial contribution to the data collection and the drafting of the manuscript and reviewed and accepted the contents of the manuscript prior to its submission.
Funding
This study was supported by the National Natural Science Foundation (Grant Numbers 82071187, 81870821, 81471215), The National Key Research and Development Program of China (2021YFC2500103), Beijing Youth Talent Team Support Program (2018000021223TD08), National Key Research and Development Program (2019YFC01209028), and Beijing Natural Science Foundation grant (L182055).
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
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Supplementary material
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fonc.2022.902301/full#supplementary-material
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Keywords: sodium oligomannate, cognitive impairment, cerebral blood flow, CAR-T, rivastigmine
Citation: Wang Y-L, Zhang Y and Xu J (2022) Sodium oligomannate combined with rivastigmine may improve cerebral blood flow and cognitive impairment following CAR-T cell therapy: A case report. Front. Oncol. 12:902301. doi: 10.3389/fonc.2022.902301
Received: 10 May 2022; Accepted: 25 July 2022;
Published: 18 August 2022.
Edited by:
Liren Qian, Fifth Medical Center of the PLA General Hospital, ChinaReviewed by:
Sanfang Tu, Southern Medical University, ChinaCiprian Tomuleasa, Iuliu Hațieganu University of Medicine and Pharmacy, Romania
Copyright © 2022 Wang, Zhang and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Jun Xu, bmV1cm9qdW5AMTI2LmNvbQ==