AUTHOR=Zhu Yong-fu , Wang Shu-Jie , Zhou Jie , Sun Ye-han , Chen You-mou , Ma Jia , Huo Xing-xing , Song Hang 

TITLE=Effects of N6-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.897895

DOI=10.3389/fonc.2022.897895

ISSN=2234-943X

ABSTRACT=<p>N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is a major internal epigenetic modification in eukaryotic mRNA, which is dynamic and reversible. m<sup>6</sup>A is regulated by methylases (“writers”) and demethylases (“erasers”) and is recognized and processed by m<sup>6</sup>A-binding proteins (“readers”), which further regulate RNA transport, localization, translation, and degradation. It plays a role in promoting or suppressing tumors and has the potential to become a therapeutic target for malignant tumors. In this review, we focus on the mutual regulation of m<sup>6</sup>A and coding and non-coding RNAs and introduce the molecular mechanism of m<sup>6</sup>A methylation involved in regulation and its role in cancer treatment by taking common female malignant tumors as an example.</p>