AUTHOR=Fang Yanglan , Wang Man , Hu Shuhong , Wang Tanzhen , Liu Yujie , Xiao Jinyan , Cai Yiming , Wang Ying , Qiu Huiying , Tang Xiaowen , Chen Suning , Wu Depei , Xu Yang , Liu Tianhui 

TITLE=Recurrent Novel P2RY8/IGH Translocations in B-Lymphoblastic Leukemia/Lymphoma

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.896858

DOI=10.3389/fonc.2022.896858

ISSN=2234-943X

ABSTRACT=<p>Translocations involving the immunoglobulin heavy chain (<italic>IGH</italic>) locus are common abnormalities in B-lymphoblastic leukemia/lymphoma (B-ALL) and multiple myeloma. These rearrangements result in a juxtaposition of <italic>IGH</italic> enhancers to the vicinity of oncogenes, such as <italic>MYC</italic> and <italic>CRLF2</italic>, leading to the upregulation of oncogenes. Here, we identified recurrent novel <italic>P2RY8/IGH</italic> translocations in three B-ALL patients by transcriptome sequencing. Noncoding exon 1 of <italic>P2RY8</italic> was translocated to different sites of the <italic>IGH</italic> gene, resulting in transcripts of <italic>P2RY8/IGHM</italic>, <italic>P2RY8/IGHV</italic>, and <italic>P2RY8/IGHD</italic>. However, a high expression level of truncated <italic>P2RY8</italic> was observed in the patients compared with healthy donors, which might be related to the aggressive clinical course and inferior outcome. In summary, we described recurrent novel <italic>P2RY8/IGH</italic> translocations with high expression levels of <italic>P2RY8</italic>, which may contribute to the guidelines for clinical diagnosis and treatment.</p>