AUTHOR=Busetto Gian Maria , D’Agostino Daniele , Colicchia Michele , Palmer Katie , Artibani Walter , Antonelli Alessandro , Bianchi Lorenzo , Bocciardi Aldo , Brunocilla Eugenio , Carini Marco , Carrieri Giuseppe , Cormio Luigi , Falagario Ugo Giovanni , De Berardinis Ettore , Sciarra Alessandro , Leonardo Costantino , Del Giudice Francesco , Maggi Martina , de Cobelli Ottavio , Ferro Matteo , Musi Gennaro , Ercolino Amelio , Di Maida Fabrizio , Gallina Andrea , Introini Carlo , Mearini Ettore , Cochetti Giovanni , Minervini Andrea , Montorsi Francesco , Schiavina Riccardo , Serni Sergio , Simeone Claudio , Parma Paolo , Serao Armando , Mangano Mario Salvatore , Pomara Giorgio , Ditonno Pasquale , Simonato Alchiede , Romagnoli Daniele , Crestani Alessandro , Porreca Angelo TITLE=Robot-Assisted, Laparoscopic, and Open Radical Cystectomy: Pre-Operative Data of 1400 Patients From The Italian Radical Cystectomy Registry JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.895460 DOI=10.3389/fonc.2022.895460 ISSN=2234-943X ABSTRACT=Introduction

The Italian Radical Cystectomy Registry (RIC) is an observational prospective study aiming to understand clinical variables and patient characteristics associated with short- and long-term outcomes among bladder cancer (BC) patients undergoing radical cystectomy (RC). Moreover, it compares the effectiveness of three RC techniques - open, robotic, and laparoscopic.

Methods

From 2017 to 2020, 1400 patients were enrolled at one of the 28 centers across Italy. Patient characteristics, as well as preoperative, postoperative, and follow-up (3, 6, 12, and 24 months) clinical variables and outcomes were collected.

Results

Preoperatively, it was found that patients undergoing robotic procedures were younger (p<.001) and more likely to have undergone preoperative neoadjuvant chemotherapy (p<.001) and BCG instillation (p<.001). Hypertension was the most common comorbidity among all patients (55%), and overall, patients undergoing open and laparoscopic RC had a higher Charlson Comorbidities Index (CCI) compared to robotic RC (p<.001). Finally, laparoscopic patients had a lower G-stage classification (p=.003) and open patients had a higher ASA score (p<.001).

Conclusion

The present study summarizes the characteristic of patients included in the RIC. Future results will provide invaluable information about outcomes among BC patients undergoing RC. This will inform physicians about the best techniques and course of care based on patient clinical factors and characteristics.