AUTHOR=Wu Kunpeng , Zhu Xiaoyan , Li Yan , Wen Daxiong , Wu Huiyu , Lai Yanzhen , Li Yun , Wu Jian , Liu Zhuoxing 

TITLE=Primary Ewing’s sarcoma of sphenoid sinus: A case report and literature review

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.894833

DOI=10.3389/fonc.2022.894833

ISSN=2234-943X

ABSTRACT=Background: Primary Ewing’s sarcoma of sphenoid sinus, observed in children and adolescents, is extremely rare malignancy. Such rarity makes the imaging features and treatment strategies for Ewing’s sarcoma of sphenoid sinus remain unclear. This study aimed to offer guidance for the treatment of this very disease by describing a patient with a rare primary Ewing’s sarcoma of sphenoid sinus and performing a review of the available data in literature.
Case Description: A case of Ewing’s sarcoma in sphenoid sinus treated with multidisciplinary treatment approaches, including tumor resection, radiotherapy, chemotherapy and antiangiogenic therapy, was hereby presented in this study; Besides, literature for Ewing’s sarcoma in the head was systematically searched, and two cases of in sphenoid sinus and five cases in the sphenoid bone were carefully identified; Furthermore, the clinical features, imaging findings, pathological characteristics, treatment, and prognosis were correspondingly summarized.
Conclusion: Tumor resection combined with radiotherapy and chemotherapy may provide favourable results for patients with Ewing’s sarcoma of sphenoid sinus and bone. However, more reports are still necessary to further clarify optimal management.