AUTHOR=Keranmu Adili , Yang Fei-Ya , Wahafu Wasilijiang , Han Su-Jun , Yang Guo-Sheng , Xing Nian-Zeng TITLE=Biotransformation of Abiraterone Into Five Characteristic Metabolites by the Rat Gut Microbiota and Liver Microsomes JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.890323 DOI=10.3389/fonc.2022.890323 ISSN=2234-943X ABSTRACT=
It is well known that the role of gut microbiota in drug metabolism, especially in oral difficult absorbable drugs. Understanding the gut microbiota could enable us to understand drugs in new ways. The purpose of the study was to investigate explore the metabolites of the anti-prostate cancer drug Abiraterone by examining gut microbiota metabolism and hepatic metabolism