AUTHOR=Sun Chun-Feng , Zhang Ding , Gao Yan , Mao Xiao-Ying , Tan Zhong-Hua , Bao Shan-Lei , Shen Chen 

TITLE=Application of Imaging Indicators Based on 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Colorectal Peritoneal Carcinomatosis

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.888680

DOI=10.3389/fonc.2022.888680

ISSN=2234-943X

ABSTRACT=Objective: This study aims to analyze the imaging presentation of colorectal peritoneal carcinomatosis (CRPC) on 18F-FDG positron emission tomography–computed tomography (PET/CT) and explore the relationship between the peritoneal cancer parameters and primary lesions of colorectal cancer (CRC). Methods: The PET/CT data of 132 patients with CRPC who met the inclusion and exclusion criteria between May 30, 2016, and December 31, 2019, were collected and analyzed. Observations included the peritoneal cancer index (PCI), standardized uptake maximum value (SUV)max, retention index (RI), CRC location, and pathological type of the primary lesion. Statistical analysis was performed using SPSS 20.0 software, and P < 0.05 was statistically significant. Results: (1) The range of PCI in 132 patients was 2 to 30, with a mean value of 7.40 ± 8.14. The maximum long diameter of the CRPC lesions ranged from 0.6 cm to 12.1 cm, with an average of 3.23 ± 1.94 cm. The SUVmax ranged from 1.2 to 31.0, with a mean value of 9.65 ± 6.01. The SUVmax and size correlation coefficient for maximal CRPC lesions was r = 0.47 (P < 0.001). The RI range of 72 patients was –10.0%–112.2% with RI quartiles of 13.5%–48.9%, with RI ≥5% in 65 cases and RI <5% in 7 cases. (2) The patients were grouped according to the CRC location, the intergroup differences in the pathological type of CRC (P = 0.009), and PCI scores (P = 0.02) between the right-sided colon cancer and rectal cancer groups, and the RI (P < 0.001) between the right-sided colon cancer group and the other two groups were statistically significant. (3) The patients were grouped according to the pathological type of CRC; the intergroup differences in the CRC location (P = 0.003) and SUVmax (P = 0.03) were statistically significant between the moderately well-differentiated and mucinous adenocarcinomas groups.Conclusion: The PCI was related to the CRC location and pathological type, and the 18F-FDG PET/CT, especially glucose metabolic function imaging, was beneficial for detecting CRPC in moderately well-differentiated adenocarcinomas.