AUTHOR=Sandmann Sarah , Behrens Yvonne Lisa , Davenport Claudia , Thol Felicitas , Heuser Michael , Dörfel Daniela , Löhr Friederike , Castrup Agnes , Steinemann Doris , Varghese Julian , Schlegelberger Brigitte , Dugas Martin , Göhring Gudrun TITLE=Clonal Evolution at First Sight: A Combined Visualization of Diverse Diagnostic Methods Improves Understanding of Leukemic Progression JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.888114 DOI=10.3389/fonc.2022.888114 ISSN=2234-943X ABSTRACT=
Patients with myeloid neoplasia are classified by the WHO classification systems. Besides clinical and hematological criteria, cytogenetic and molecular genetic alterations highly impact treatment stratification. In routine diagnostics, a combination of methods is used to decipher different types of genetic variants. Eight patients were comprehensively analyzed using karyotyping, fluorescence