AUTHOR=Hou Xuefei , Yue Suru , Liu Jie , Qiu Zhiqing , Xie Liming , Huang Xueying , Li Shasha , Hu Liren , Wu Jiayuan TITLE=Association of Tumor Size With Prognosis in Patients With Resectable Endometrial Cancer: A SEER Database Analysis JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.887157 DOI=10.3389/fonc.2022.887157 ISSN=2234-943X ABSTRACT=
This study aimed to explore the relationship between tumor size (Ts) and prognosis in endometrial cancer (EC). A total of 52,208 patients with EC who underwent total hysterectomy were selected from the Surveillance, Epidemiology, and End Results Program database. Overall survival (OS) and endometrial cancer-specific survival (ESS) were chosen as survival outcomes. The Cox proportional hazards model was used to explore the effect of Ts on prognosis. The restricted cubic splines based on the Cox regression model were used to determine the nonlinear relationship between Ts and survival. When Ts was analyzed as a categorical variable, the risk of death increased with Ts, with the highest risk in patients with Ts > 9 cm with regard to all-cause death (ACD) (hazard ratio [HR] 1.317; 95% confidence interval [CI], 1.196-1.450;