AUTHOR=Wang Juan , Wang Xiaoya , Zhang Xintong , Shao Tingting , Luo Yanmei , Wang Wei , Han Yunwei 

TITLE=Extracellular Vesicles and Hepatocellular Carcinoma: Opportunities and Challenges

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.884369

DOI=10.3389/fonc.2022.884369

ISSN=2234-943X

ABSTRACT=<p>The incidence of hepatocellular carcinoma (HCC) is increasing worldwide. Extracellular vesicles (EVs) contain sufficient bioactive substances and are carriers of intercellular information exchange, as well as delivery vehicles for nucleic acids, proteins and drugs. Although EVs show great potential for the treatment of HCC and their role in HCC progression has been extensively studied, there are still many challenges such as time-consuming extraction, difficult storage, easy contamination, and low drug loading rate. We focus on the biogenesis, morphological characteristics, isolation and extraction of EVs and their significance in the progression of HCC, tumor invasion, immune escape and cancer therapy for a review. EVs may be effective biomarkers for molecular diagnosis of HCC and new targets for tumor-targeted therapy.</p>