AUTHOR=Shen Wenyue , Zhou Quanwei , Peng Chenxi , Li Jiaheng , Yuan Qizhi , Zhu Hecheng , Zhao Ming , Jiang Xingjun , Liu Weidong , Ren Caiping 

TITLE=FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and Prospective Strategies

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.880077

DOI=10.3389/fonc.2022.880077

ISSN=2234-943X

ABSTRACT=<p>FBXW7, a member of the F-box protein family within the ubiquitin–proteasome system, performs an indispensable role in orchestrating cellular processes through ubiquitination and degradation of its substrates, such as c-MYC, mTOR, MCL-1, Notch, and cyclin E. Mainly functioning as a tumor suppressor, inactivation of FBXW7 induces the aberrations of its downstream pathway, resulting in the occurrence of diseases especially tumorigenesis. Here, we decipher the relationship between FBXW7 and the hallmarks of cancer and discuss the underlying mechanisms. Considering the interplay of cancer hallmarks, we propose several prospective strategies for circumventing the deficits of therapeutic resistance and complete cure of cancer patients.</p>