AUTHOR=Mahmoodi Ardalan , Shoqafi Ahmed , Sun Ping , Giannakeas Vasily , Cybulski Cezary , Nofech-Mozes Sharon , Masson Jean-Yves , Sharma Sudha , Samani Amir Abbas , Madhusudan Srinivasan , Narod Steven A. , Akbari Mohammad R. TITLE=High Expression of RECQL Protein in ER-Positive Breast Tumours Is Associated With a Better Survival JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.877617 DOI=10.3389/fonc.2022.877617 ISSN=2234-943X ABSTRACT=Background

RECQL (also known as RECQ1 and RECQL1) is a gene of recent interest in breast cancer and an association between high levels of RECQL protein in breast cancer tumour cells and good survival of patients has been reported.

Methods

To validate this association, we measured the RECQL protein levels in tumours of 933 breast cancer patients using immunohistochemistry analysis and followed the patients for death from breast cancer.

Results

Women with a level of RECQL protein above the 75th percentile had better 15-year disease-specific survival among ER-positive patients (62.5% vs. 48.7%, HR= 0.72, 95%CI= 0.52-0.98, p-value = 0.04), but not among ER- patients (48.9% vs. 48.0%, HR= 1.07, 95%CI= 0.67-1.69, p-value= 0.79). Among the ER-negative patients, high RECQL protein levels were associated with better survival among women who received tamoxifen treatment (67.0% vs. 51.5%, HR= 0.64, 95%CI= 0.41-0.99, p-value= 0.04).

Conclusion

RECQL might be a new predictive marker for tamoxifen treatment among ER-positive patients.