AUTHOR=Ghafouri-Fard Soudeh , Khoshbakht Tayyebeh , Hussen Bashdar Mahmud , Jamal Hazha Hadayat , Taheri Mohammad , Hajiesmaeili Mohammadreza 

TITLE=A Comprehensive Review on Function of miR-15b-5p in Malignant and Non-Malignant Disorders

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.870996

DOI=10.3389/fonc.2022.870996

ISSN=2234-943X

ABSTRACT=<p>miR-15b-5p is encoded by <italic>MIR15B</italic> gene. This gene is located on cytogenetic band 3q25.33. This miRNA participates in the pathogenesis of several cancers as well as non-malignant conditions, such as abdominal aortic aneurysm, Alzheimer’s and Parkinson’s diseases, cerebral ischemia reperfusion injury, coronary artery disease, dexamethasone induced steatosis, diabetic complications and doxorubicin-induced cardiotoxicity. In malignant conditions, both oncogenic and tumor suppressor impacts have been described for miR-15b-5p. Dysregulation of miR-15b-5p in clinical samples has been associated with poor outcome in different kinds of cancers. In this review, we discuss the role of miR-15b-5p in malignant and non-malignant conditions.</p>