AUTHOR=Internò Valeria , Triggiano Giacomo , De Santis Pierluigi , Stucci Luigia Stefania , Tucci Marco , Porta Camillo 

TITLE=Molecular Aberrations Stratify Grade 2 Astrocytomas Into Several Rare Entities: Prognostic and Therapeutic Implications

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.866623

DOI=10.3389/fonc.2022.866623

ISSN=2234-943X

ABSTRACT=<p>The identification of specific molecular aberrations guides the prognostic stratification and management of grade 2 astrocytomas. Mutations in isocitrate dehydrogenase (<italic>IDH</italic>) 1 and 2, found in the majority of adult diffuse low-grade glioma (DLGG), seem to relate to a favorable prognosis compared to <italic>IDH</italic> wild-type (<italic>IDH</italic>-wt) counterparts. Moreover, the <italic>IDH</italic>-wt group can develop additional molecular alterations worsening the prognosis, such as epidermal growth factor receptor amplification (<italic>EGFR-</italic>amp) and mutation of the promoter of telomerase reverse transcriptase (<italic>pTERT-mut</italic>). This review analyzes the prognostic impact and therapeutic implications of genetic alterations in adult LGG.</p>