AUTHOR=Li Zhifang , Zhang Wenqing , Bai Jinyang , Li Jing , Li Hong 

TITLE=Emerging Role of Helicobacter pylori in the Immune Evasion Mechanism of Gastric Cancer: An Insight Into Tumor Microenvironment-Pathogen Interaction

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.862462

DOI=10.3389/fonc.2022.862462

ISSN=2234-943X

ABSTRACT=<p><italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>) infection is the strongest causative factor of gastric cancer. Growing evidence suggests that the complex crosstalk of <italic>H. pylori</italic> and the tumor microenvironment (TME) exerts a profound influence on gastric cancer progression. Hence, there is emerging interest to in-depth comprehension of the mechanisms of interplay between <italic>H. pylori</italic> and the TME. This review discusses the regulatory mechanisms underlying the crosstalk between <italic>H. pylori</italic> infection and immune and stromal cells, including tumor-associated macrophages (TAMs), neutrophils, dendritic cells, myeloid-derived suppressor cells (MDSCs), natural killer (NK) cells, B and T cells, cancer associated fibroblasts (CAFs), and mesenchymal stem cells (MSCs), within the TME. Such knowledge will deepen the understanding about the roles of <italic>H. pylori</italic> in the immune evasion mechanism in gastric cancer and contribute to the development of more effective treatment regimens against <italic>H. pylori</italic>-induced gastric cancer.</p>