AUTHOR=Tong Yiwei , Zhu Siyi , Chen Weiguo , Chen Xiaosong , Shen Kunwei 

TITLE=Association of Obesity and Luminal Subtypes in Prognosis and Adjuvant Endocrine Treatment Effectiveness Prediction in Chinese Breast Cancer Patients

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.862224

DOI=10.3389/fonc.2022.862224

ISSN=2234-943X

ABSTRACT=<sec><title>Purpose</title><p>To evaluate the influence of obesity on clinicopathological characteristics of breast cancer; to explore the effect of obesity on the prognosis and performance of endocrine therapy in breast cancer patients.</p></sec><sec><title>Methods</title><p>Patients with luminal/HER2-negative early breast cancer were included and categorized into the non-obese (BMI&lt;28kg/m<sup>2</sup>) and obese (BMI≥28kg/m<sup>2</sup>) groups according to body mass index (BMI). Clinicopathological characteristics and treatment modalities were compared between groups. Interaction of adjuvant endocrine therapy with obesity was analyzed.</p></sec><sec><title>Results</title><p>A total of 2,875 patients were included: 2,598 non-obese and 277 obese. A higher rate of patients with comorbidities (OR: 2.83, 95%CI 2.13-3.74, <italic>P</italic>&lt;0.001) or PR-positive tumor (OR: 1.63, 95%CI 1.03-2.58, <italic>P</italic>=0.037) were identified in the obese group. Obesity was not associated with disease recurrence (<italic>P</italic>=0.839) or overall survival (<italic>P</italic>=0.140) in the whole population. Subgroup analysis did show an association with worse relapse-free survival (RFS, HR 3.48, 95%CI 1.31-9.22, <italic>P</italic>=0.012) and overall survival (OS, HR 4.67, 95%CI 1.28-16.95, <italic>P</italic>=0.019) in luminal A breast cancer. These results could not be reproduced in the luminal B subtype with a RFS (HR 0.78, 95%CI 0.41-1.49, <italic>P</italic>=0.454) or OS (HR 1.17, 95%CI 0.50-2.74, <italic>P</italic>=0.727). Furthermore, obesity did not impact endocrine therapy effectiveness in Tamoxifen or the aromatase inhibitor group (RFS: interact <italic>P</italic>=0.381; OS: interact <italic>P</italic>=0.888).</p></sec><sec><title>Conclusions</title><p>The impact of obesity on prognosis interacted with luminal subtype status in Chinese breast cancer patients which was not related with endocrine treatment modality.</p></sec>