AUTHOR=Chen Xi , Zhou Fan , Ren Wenjun , Guo Jishu , Huang Xiaobin , Pu Jun , Niu Xiaoqun , Jiang Xiulin 

TITLE=LncRNA-AC02278.4 Is a Novel Prognostic Biomarker That Promotes Tumor Growth and Metastasis in Lung Adenocarcinoma

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.860961

DOI=10.3389/fonc.2022.860961

ISSN=2234-943X

ABSTRACT=LncRNA-AC02278.4 (ENSG00000248538) is a long non-coding RNA (lncRNA) found to be highly expressed in multiple human cancers including lung adenocarcinoma (LUAD). However, the underlying biological function and potential mechanisms of AC02278.4 driving the progression of lung adenocarcinoma remains unclear. In this study, we investigated the role of AC02278.4 in lung adenocarcinoma and found that AC02278.4 expression was significantly increased in datasets extracted from The Cancer Genome Atlas. Increased expression of lncRNA-AC02278.4 was correlated with advanced clinical parameters. Receiver operating curve (ROC) analysis revealed the significant diagnostic ability of AC02278.4 (AUC = 0.882). In addition, GSEA enrichment showed that AC02278.4 expression was correlated with immune-response related signaling pathway. Finally, we determined that AC02278.4 regulated cell proliferation and migration of lung adenocarcinoma in vitro. Our clinical sample results also confirmed that AC02278.4 was highly expressed in LUAD and correlated with adverse clinical outcomes. In conclusion, our data demonstrated that AC02278.4 was correlated with progression and immune infiltration, and could serve as a prognostic biomarker for lung adenocarcinoma.