AUTHOR=Espiritu Adrian I. , Larrazabal Ramon B. , Sy Marie Charmaine C. , Villanueva Emilio Q. , Anlacan Veeda Michelle M. , Jamora Roland Dominic G. 

TITLE=Outcomes and Risk Factors of Patients With COVID-19 and Cancer (ONCORONA): Findings from The Philippine CORONA Study

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.857076

DOI=10.3389/fonc.2022.857076

ISSN=2234-943X

ABSTRACT=<sec><title>Background</title><p>A study conducted in China on patients with coronavirus disease 2019 (COVID-19) showed that cancer conferred a five times increased risk for needing intensive care admission and mortality; No data has yet been collected and published from the Philippines. Thus, the investigators conducted this substudy to determine the association of having a history of cancer with clinical outcomes among patients included in the Philippine CORONA Study.</p></sec><sec><title>Methodology</title><p>Multi-center, retrospective cohort design</p></sec><sec><title>Results</title><p>A total of 244 patients had a history of cancer, out of 10,881 COVID-19 hospital admissions. After adjusting for different confounding variables of interest, having cancer was significantly associated with a 75% increased odds of having severe/critical COVID-19 at nadir (CI 95% 1.32, 2.33; <italic>p</italic> &lt; 0.001). After adjusting for different confounding variables of interest, having cancer was significantly associated with the following time-to-event outcomes: 72% increase in hazard of in-hospital mortality (CI 95% 1.37, 2.16; <italic>p</italic> &lt; 0.001), 65% increase in hazard of respiratory failure (CI 95% 1.31, 2.08; <italic>p</italic> &lt; 0.001), and 57% increase in hazard of being admitted to ICU (CI 95% 1.24, 1.97; <italic>p</italic> &lt; 0.001).</p></sec><sec><title>Conclusion</title><p>A history of cancer conferred poorer clinical outcomes on adult, hospitalized COVID-19 patients.</p></sec>