AUTHOR=Huang Chenglu , Xu Suqin , Luo Zhilin , Li Dong , Wang Rui , Wang Tianhu 

TITLE=Epidemiological Evidence Between Variants in Matrix Metalloproteinases-2, -7, and -9 and Cancer Risk

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.856831

DOI=10.3389/fonc.2022.856831

ISSN=2234-943X

ABSTRACT=<sec><title>Background</title><p>Matrix metalloproteinases (<italic>MMP</italic>s), a kind of proteases, have a critical function in cancer occurrence, invasion, and migration. <italic>MMP</italic> gene variants (e.g., <italic>MMP-2</italic>, <italic>MMP-7</italic>, and <italic>MMP-9</italic>) can affect the biological functions of these enzymes and lead to the occurrence and progression of cancer, which has become a hot topic in recent years, but the corresponding results are still controversial. In this context, here, the meta-analysis was conducted for assessing the relations of variants in <italic>MMP-2</italic>, <italic>MMP-7</italic>, and <italic>MMP-9</italic> with the risk of various cancers.</p></sec><sec><title>Methods</title><p>PubMed, Web of Science, and Medline were systemically searched, and data were extracted from all eligible studies so as to investigate the susceptibility of <italic>MMP-2</italic>, <italic>MMP-7</italic>, and <italic>MMP-9</italic> to different types of cancers. The association between a variant in <italic>MMP</italic> and cancer susceptibility was analyzed through odds ratios (ORs) as well as 95% CIs. The Venice criteria and false-positive report probability (FPRP) were adopted to evaluate epidemiological evidence of significant associations discovered.</p></sec><sec><title>Results</title><p>The associations between the variants of <italic>MMP</italic>s and cancer risk in 36,530 cases and 41,258 controls were found, with 12 associations (<italic>MMP-2</italic> rs243865 with esophageal cancer and lung cancer, <italic>MMP-7</italic> rs11568818 with bladder and cervical cancer, and <italic>MMP-9</italic> rs3918242 with breast cancer) rated as strong associations for cancer risk and 7 and 15 as moderate and weak associations, respectively. These significant associations were mostly found in Asians.</p></sec><sec><title>Conclusions</title><p>These findings support the relations between variants of <italic>MMP-2</italic>, <italic>MMP-7</italic>, and <italic>MMP-9</italic> and various cancers risk, demonstrating the credibility of these relations.</p></sec>