AUTHOR=de Almeida Liz Maria , Cortés Sandra , Vilensky Marta , Valenzuela Olivia , Cortes-Sanabria Laura , de Souza Mirian , Barbeito Rafael Alonso , Abdelhay Eliana , Artagaveytia Nora , Daneri-Navarro Adrian , Llera Andrea S. , Müller Bettina , Podhajcer Osvaldo L. , Velazquez Carlos , Alcoba Elsa , Alonso Isabel , Bravo Alicia I. , Camejo Natalia , Carraro Dirce Maria , Castro Mónica , Cataldi Sandra , Cayota Alfonso , Cerda Mauricio , Colombo Alicia , Crocamo Susanne , Del Toro-Arreola Alicia , Delgadillo-Cristerna Raul , Delgado Lucia , Breitenbach Marisa Dreyer , Fernández Elmer , Fernández Jorge , Fernández Wanda , Franco-Topete Ramon A. , Gaete Fancy , Gómez Jorge , Gonzalez-Ramirez Leivy P. , Guerrero Marisol , Gutierrez-Rubio Susan A. , Jalfin Beatriz , Lopez-Vazquez Alejandra , Loria Dora , Míguez Silvia , Moran-Mendoza Andres de J. , Morgan-Villela Gilberto , Mussetti Carina , Nagai Maria Aparecida , Oceguera-Villanueva Antonio , Reis Rui M. , Retamales Javier , Rodriguez Robinson , Rosales Cristina , Salas-Gonzalez Efrain , Segovia Laura , Sendoya Juan M. , Silva-Garcia Aida A. , Viña Stella , Zagame Livia , Jones Beth , Szklo Moysés , United States-Latin American Cancer Research Network (US-LACRN) , Abarca Juan , Acevedo Pamela , Acosta Graciela , Acosta Ana , Haab Gabriela Acosta , Acosta-Torres Keyla Teresa , Aghazarian Marta , Aguayo Carola , Alarcon-Lopez Gustavo , Andrade Viviane , Bueno Wenceslao Angeles , Arai Roberto , Arambula-Barreras Priscila Elvira , Arámburo-Rubio Maria Isabel , Araus Estrellita , Ardao Gonzalo , Arellano-Jimenez Lilia A. , Argandoña Felipe , Arias Claudia , Armisen Ricardo , Aspee Mauricio , Assar Rodrigo , Astiazarán-Rascón Itzel Reneé , Astorga Sebastian , Avilés-Rodrıguez Maxwell , Junior Antônio Bailão , Barragan-Curiel Adolfo E. , Barragan-Ruiz Adelfo , Bernachin Julia , Bernal-Herrera Wilfrido , Binato Renata , Brnich Sarah , Bustamante Claudio , Bustamante Miguel Angel , Gomez Julio Bustos , de J. Bustos Rodriguez Felipe , Caballero-Jasso Janett , Calfuman Angie , Hugo Antonio , Campos José Froes Marques , Campos Mónica , Cano Soledad , Canton-Romero Juan C. , Carmona Paulina , Carrizo Fernando , Carvalho Andre Lopes , Carvallo Erika , Carzoglio Julio , Casalnuovo Monica , Caserta Benedicta , Castillo Alvaro , Castillo César , Castro-Cervantes Juan M. , Cerda Yascara , Chammas Roger , Chavez-Zamudio Mario Alberto , Chia Loreto , Chirico Daniela , Cisneros-Quirarter Esther , Cordero-Bautista Minor Raul , Cornejo Valeria , Corral-Villegas Baldemar , Cortés Andrés , Cortez-Zamorano German Salvador , Corvalan Alejandro , Cruz Adolfo , d’Aurora Alba , De la Fuente Sandra , De la Peña Soledad , de Leon-Caballero Roberto , Del Castillo César , Del-Toro-Valero Azucena , Di Pretoro Mirtha , Digonzelli Andrea , El Ters Jose , Escobar Paula , Estolaza Marcela , Evangelista Adriane Feijo , Fanelli Marcelo , Farias Paulo , Flaks Diego , Flores-Ayala Edgar G. , Flores-Marquez Maria R. , Franco-Hughes David , Franco-Topete Karina , Fresno Cristobal , Gabay Carolina , Gallegos Mario , Gamboa Jorge , Ganiewich Daiana , Garbovesky Carlos , Garcia-Gaeta Ricardo , Garcia-Martinez Alma C. , Garcıa-Munguıa Rubén Alejandro , Garibay-Escobar Adriana , Gimenez Liliana , Gomez-Del Toro Mariana M. , González Germán , González Mondaca César Osbaldo , Gonzalez-Ramirez Leivy P. , Gonzalez-Ulloa Beatriz , Gorostidy Susana , Greif Gonzalo , Guevara-Torres Alfonso G. , Gutierrez Lorena , Hannois Adrián , Hart Andrew , Härtel Steffen , Henriquez Marcos , Hernandez-Franco Miriam E , Hernandez-Guevara Rafael , Herrera-Miramontes Manuel I , Horton Graciela , Ibañez Gladys , Ipiña Martın , Jara Lilian , Jara Raul , Jaramillo Maria Luisa , Jardim Beatriz , Jimenez Maria Eugenia , Jimenez-Moreno Victor M. , Ju Hugo , Rusjan Nazareth Juárez , Juneman Karen , Kerr Ligia Maria , Krupelis Alejandra , Laviña Guillermo , Lavista Fernando , León-Duarte Irma Leticia , Lescano Alberto , Lezano Verónica , Lopez Rossana Mendoza , López-Cervantes Jose Guillermo , Lopez-Muñoz Miguel Enrique , Lucena Francisca , Luque Alejandra , Maass Alejandro , do Socorro Maciel Maria , Maldonado Silvina , Mangone Flavia Rotea , Mansilla Jorge , Marcelain Katherine , Mariani Carolina , Marques Marcia Maria Chiquitelli , Martinez-Arriaga Reyna J , Martinez-Ramirez Hector R , Martins Marcela , Maya-Gonzalez Alma G , Menini Mariana , Milans Soledad , Montes Soledad , Hernández Ana Verónica Morales , Morong Carla , Mussetti Eduardo , Najar-Acosta Luis J , Napolitano e Ferreira Elisa , Ruiz Nancy E Navarro , Noblıa Cristina , Nunes João Soares , Núñez Fabiola , Onari Nilton , Oropeza-De Anda Emma M , Ortega-Tirado David , Ortiz-Martinez Miguel Angel , Bueno de Toledo Osório Cynthia Aparecida , Paiva Carlos Eduardo , Peñaloza Paulina , Navarro Miguel Peredo , Pereira David , Perez-Michel Laura , Pino Francisca , Pino Tania , Pinto Natalia , Pizarro Jessica , Quintero Jael , Quintero-Ramos Antonio , Ramirez Enrique , Ramirez-Rosales Gladys E , Ramis Claudia , Ramirez Maritza Ramos , Rascon-Alcantar Adela , Richard Francois , Rios-Méndez Omar , Rivera-Claisse Ernesto , Robles-Zepeda Ramón E. , Rocha Iara Santana , Rodriguez Natalia , Rodriguez Vilma , Rodriguez Maria Teresa , Rodriguez-Gonzalez Diego , Roela Rosemeire A , Romero-Gomez Ana M. , Rosales-Sandoval Ana M. , Rubio-Chavez Lidia A. , Rubio-Plascencia Omar V. , Russo Florencia , Sabini Gaciela , Saffie Isabel , Samaniego Brenda , Sanchez-Llamas Benito , Sanchotena Verónica , Sat-Muñoz Daniel , Savignano Mariana , Neto Cristovam Scapulatempo , Senna Max Mano , Silva Carolina , Silvera Jaime , Small Isabele , Soares Fernando , Soares Iberê , dos Santos Silvana Soares , de Mello Evandro Sobrosa , Sola José Antonio , Sorın Irene , Sosa Alejandra , Sosa Claudio , de Pádua Souza Cristiano , Spangenberg Lucıa , Steffanof Gustavo , Straminsky Florencia , Tapia Mónica , Tapia-Llanos Raziel O. , Tavares-Macias Geronimo M. , Terzieff Veronica , Teti Vicente , Tognarelli Javier , Toledo Verónica , Toro Paulina , Torres Roberto , Torres-Palomares Mariana , Trinchero Alejandra , Roman Rogelio Troyo-San , Urbano Hernan , Vacca Nicolas , Valencia-Peña Marıa Lourdes , Nares Jaime Vazquez , Velez-Gomez Ezequiel , Venegas-Godinez Laura N. , Verdugo Ricardo , da Costa Vieira René Aloisio , Villegas-Gómez Manuel Isaac , Vornetti Silvia , Watanabe Anapaula H. U. , Zamorano Carlos , Zapata Luis , Zlatar Zdenka TITLE=Socioeconomic, Clinical, and Molecular Features of Breast Cancer Influence Overall Survival of Latin American Women JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.845527 DOI=10.3389/fonc.2022.845527 ISSN=2234-943X ABSTRACT=

Molecular profile of breast cancer in Latin-American women was studied in five countries: Argentina, Brazil, Chile, Mexico, and Uruguay. Data about socioeconomic characteristics, risk factors, prognostic factors, and molecular subtypes were described, and the 60-month overall cumulative survival probabilities (OS) were estimated. From 2011 to 2013, 1,300 eligible Latin-American women 18 years or older, with a diagnosis of breast cancer in clinical stage II or III, and performance status ≦̸1 were invited to participate in a prospective cohort study. Face-to-face interviews were conducted, and clinical and outcome data, including death, were extracted from medical records. Unadjusted associations were evaluated by Chi-squared and Fisher’s exact tests and the OS by Kaplan–Meier method. Log-rank test was used to determine differences between cumulative probability curves. Multivariable adjustment was carried out by entering potential confounders in the Cox regression model. The OS at 60 months was 83.9%. Multivariable-adjusted death hazard differences were found for women living in Argentina (2.27), Chile (1.95), and Uruguay (2.42) compared with Mexican women, for older (≥60 years) (1.84) compared with younger (≤40 years) women, for basal-like subtype (5.8), luminal B (2.43), and HER2-enriched (2.52) compared with luminal A subtype, and for tumor clinical stages IIB (1.91), IIIA (3.54), and IIIB (3.94) compared with stage IIA women. OS was associated with country of residence, PAM50 intrinsic subtype, age, and tumor stage at diagnosis. While the latter is known to be influenced by access to care, including cancer screening, timely diagnosis and treatment, including access to more effective treatment protocols, it may also influence epigenetic changes that, potentially, impact molecular subtypes. Data derived from heretofore understudied populations with unique geographic ancestry and sociocultural experiences are critical to furthering our understanding of this complexity.