AUTHOR=Mirallas Oriol , Bosch-Schips Marc , Pardo Nuria , Aubanell Anton , Salcedo-Allende Maria Teresa , Callejo Ana , Iranzo Patricia , Tabernero Josep , Felip Enriqueta 

TITLE=Hepatic Rupture as the Initial Presentation of an EGFR-Mutated Lung Adenocarcinoma: A Case Report

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.837630

DOI=10.3389/fonc.2022.837630

ISSN=2234-943X

ABSTRACT=<p>Hepatic rupture is a rare complication of solid tumor malignancies, notably in lung adenocarcinomas, and carries an extremely poor overall prognosis. Epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma predict benefit with tyrosine kinase inhibitors (TKIs). This case report describes a female patient who presented with a metastatic hepatic rupture and was subsequently diagnosed with <italic>EGFR</italic>-mutated lung adenocarcinoma. The tumor had an impressive response to TKI inhibitor treatment, reversing her extremely poor, short-term prognosis. We believe this unique case sheds light on the treatment management of hepatic ruptures and supports the high response rate seen with TKIs in <italic>EGFR</italic>-mutated lung cancers, regardless of the patient’s performance status.</p>