AUTHOR=Kaplon Hélène 

TITLE=Translational Learnings in the Development of Chemo-Immunotherapy Combination to Bypass the Cold Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.835502

DOI=10.3389/fonc.2022.835502

ISSN=2234-943X

ABSTRACT=Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancer, with a 5-year relative 
survival rate of 5%. The desmoplastic stroma found in the tumor microenvironment of PDAC is 
suggested to be partly responsible to the resistance to most therapeutic strategies. This review outlines the clinical results get with immune checkpoint inhibitor in PDAC and discuss the rationale to use a combination of chemotherapy and immune checkpoint therapy. Moreover, essential parameters to take in account to design an efficient combination have been highlighted.