AUTHOR=Chen Yu , Fan Zhihua , Hu Shen , Lu Chengchao , Xiang Yi , Liao Shuzhi 

TITLE=Ferroptosis: A New Strategy for Cancer Therapy

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.830561

DOI=10.3389/fonc.2022.830561

ISSN=2234-943X

ABSTRACT=<p>Ferroptosis is a newly discovered form of iron-dependent cell death, which is different from other death forms. The main characteristics of ferroptosis are: (1) Amino acid metabolism. (2) Iron metabolism; (3) Lipid metabolism and Reactive oxygen species (ROS). Ferroptosis is related to the occurrence and development of a variety of cancers, especially in the drug resistance. This article reviews the research progress of iron death in tumors, and provides a theoretical reference for its further research and clinical application.</p>