AUTHOR=Cui Ying , Liu Yao , Mu Lan , Li Yang , Wu Gang 

TITLE=Transcriptional Expressions of ALDH1A1/B1 as Independent Indicators for the Survival of Thyroid Cancer Patients

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.821958

DOI=10.3389/fonc.2022.821958

ISSN=2234-943X

ABSTRACT=<sec><title>Background</title><p>Aldehyde dehydrogenase (ALDH) 1 is an important enzyme involved in the regulation of several cellular mechanisms <italic>via</italic> aldehyde detoxification. High ALDH1 levels were correlated with tumorigenesis and stemness maintenance in cancer.</p></sec><sec><title>Methods</title><p>We used UALCAN, Human Protein Atlas, Kaplan–Meier plotter, TISIDB, TIMER, and KOBAS databases to investigate the expression and role of ALDH1 in thyroid cancer progression. In addition, quantitative real-time polymerase chain reaction was performed to detect the expression of the target genes in thyroid cancer cell lines and cancer tissues.</p></sec><sec><title>Results</title><p>Expression of ALDH1A1/B1 was significantly decreased based on individual cancer stages and tumor histology, and high levels of ALDH1A1/B1 were associated with poor overall survival in thyroid cancer patients. Moreover, ALDH1A1/B1 expression was negatively correlated with immune-stimulating genes, major histocompatibility complex, chemokines, and receptors.</p></sec><sec><title>Conclusions</title><p>These results suggest that ALDH1A1/B1 might serve as potential prognostic biomarkers for thyroid cancer diagnosis.</p></sec>