AUTHOR=Yang Jinpu , Liu Xia , Cheng Yiwen , Zhang Jingchen , Ji Feng , Ling Zongxin 

TITLE=Roles of Plasmacytoid Dendritic Cells in Gastric Cancer

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.818314

DOI=10.3389/fonc.2022.818314

ISSN=2234-943X

ABSTRACT=<p>Gastric cancer (GC) is the fifth most common neoplasm and the third most deadly cancer in humans worldwide. <italic>Helicobacter pylori</italic> infection is the most important causative factor of gastric carcinogenesis, and activates host innate and adaptive immune responses. As key constituents of the tumor immune microenvironment, plasmacytoid dendritic cells (pDCs) are increasingly attracting attention owing to their potential roles in immunosuppression. We recently reported that pDCs have vital roles in the development of immunosuppression in GC. Clarifying the contribution of pDCs to the development and progression of GC may lead to improvements in cancer therapy. In this review, we summarize current knowledge regarding immune modulation in GC, especially the roles of pDCs in GC carcinogenesis and treatment strategies.</p>