AUTHOR=Song Xiao-chen , Wang Yong-xue , Yu Mei , Cao Dong-yan , Yang Jia-xin 

TITLE=Case Report: Management of Recurrent Ovarian Squamous Cell Carcinoma With PD-1 Inhibitor

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.789228

DOI=10.3389/fonc.2022.789228

ISSN=2234-943X

ABSTRACT=<p>Malignant transformations, such as ovarian squamous cell carcinoma (SCC) in ovarian mature cystic teratoma (OMCT), are rare tumors. The management of recurrent disease is still a challenge, and the gene mutations involved remain unclear. We herein report a recurrent case of ovarian SCC with a PIK3CA gene variation and immunohistochemical staining of programmed death-ligand 1 (PD-L1) &gt;10%. This patient achieved clinical remission after platinum-based effective chemotherapy and programmed death 1 (PD-1) immunotherapy.</p>