AUTHOR=Xie Cuiying , Gu Ancheng , Khan Muhammad , Yao Xiangcao , Chen Leping , He Jiali , Yuan Fumiao , Wang Ping , Yang Yufan , Wei Yerong , Tang Fang , Su Hualong , Chen Jiamin , Li Jinxia , Cen Bohong , Xu Zhongyuan 

TITLE=Opportunities and challenges of hepatocellular carcinoma organoids for targeted drugs sensitivity screening

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1105454

DOI=10.3389/fonc.2022.1105454

ISSN=2234-943X

ABSTRACT=<p>Hepatocellular carcinoma is one of the malignancies worldwide with a high mortality rate and an increasing incidence. Molecular Targeted agents are its common first-line treatment. Organoid technology, as a cutting-edge technology, is gradually being applied in the development of therapeutic oncology. Organoid models can be used to perform sensitivity screening of targeted drugs to facilitate the development of innovative therapeutic agents for the treatment of hepatocellular carcinoma. The purpose of this review is to provide an overview of the opportunities and challenges of hepatocellular carcinoma organoids in targeted drug sensitivity testing as well as a future outlook.</p>