AUTHOR=Giglio Fabio , Campodonico Edoardo , Lorentino Francesca , Noviello Maddalena , Xue Elisabetta , Greco Raffaella , Lazzari Lorenzo , Bruno Alessandro , Lupo Stanghellini Maria Teresa , Carrabba Matteo Giovanni , La Starza Roberta , Casucci Monica , Bonini Chiara , Chiaretti Sabina , Peccatori Jacopo , Foà Robin , Ciceri Fabio TITLE=Case report: Ponatinib as a bridge to CAR-T cells and subsequent maintenance in a patient with relapsed/refractory Philadelphia-like acute lymphoblastic leukemia JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2023 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1100105 DOI=10.3389/fonc.2022.1100105 ISSN=2234-943X ABSTRACT=

Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) constitutes a heterogeneous subset of ALL with a uniformly unfavorable prognosis. The identification of mutations amenable to treatment with tyrosine kinase-inhibitors (TKIs) represents a promising field of investigation. We report the case of a young patient affected by relapsed/refractory Ph-like ALL treated with chimeric antigen receptor T (CAR-T) cells after successful bridging with compassionate-use ponatinib and low-dose prednisone. We restarted low-dose ponatinib maintenance three months later. Twenty months later, measurable residual disease negativity and B-cell aplasia persist. To the best of our knowledge, this is the first case reporting the use of ponatinib in Ph-like ALL as a bridge to and maintenance after CAR-T cell therapy.