AUTHOR=Khanmohammadi Shaghayegh , Saeedi Moghaddam Sahar , Azadnajafabad Sina , Rezaei Negar , Esfahani Zahra , Rezaei Nazila , GBD 2019 NAME Tracheal, Bronchus and Lung Cancer Collaborators , Naghavi Mohsen , Larijani Bagher , Farzadfar Farshad , Khanmohammadi Shaghayegh , Moghaddam Sahar Saeedi , Azadnajafabad Sina , Rezaei Negar , Esfahani Zahra , Rezaei Nazila , Abbasi-Kangevari Mohsen , Abbasi-Kangevari Zeinab , Abdoun Meriem , Abrehdari-Tafreshi Zahra , Abu-Zaid Ahmed , Ahmad Aqeel , Ahmadi Sepideh , Hamad Hanadi Al , Hospital Rumailah , Alessy Saleh Ali , Aljunid Syed Mohamed , Amir-Behghadami Mehrdad , Ansari-Moghaddam Alireza , Arabloo Jalal , Azangou-Khyavy Mohammadreza , Baghcheghi Nayereh , Bajbouj Khuloud , Bijani Ali , Bilalaga Mariah Malak , Bouaoud Souad , Calina Daniela , Cho William C S , Da’ar Omar B , Djalalinia Shirin , Elghazaly Hesham , Elhadi Muhammed , Ezzeddini Rana , Feizkhah Alireza , Ghashghaee Ahmad , Golitaleb Mohamad , Avval Atlas Haddadi , Hafezi-Nejad Nima , Hamadeh Randah R , Jalili Mahsa , Jamshidi Elham , Karimi Amirali , Khader Yousef Saleh , Khanali Javad , Kompani Farzad , Koohestani Hamid Reza , Bicer Burcu Kucuk , Mafi Ahmad R , Mahmoodpoor Ata , Malekpour Mohammad-Reza , Malik Ahmad Azam , Mirfakhraie Reza , Mohammadi Esmaeil , Momtazmanesh Sara , Moradzadeh Rahmatollah , Moraga Paula , Natto Zuhair S , Noori Maryam , Perna Simone , Pezzani Raffaele , AIROB (Associazione Italiana Ricerca Oncologica di Base) , Pirestani Majid , Langroudi Ashkan Pourabhari , Rabiee Mohammad , Rabiee Navid , Rahmani Shayan , Redwan Elrashdy Moustafa Mohamed , Rezaei Nima , Roshandel Gholamreza , Sadeghi Erfan , Farrokhi Amir Salek , Samy Abdallah M , Sathian Brijesh , Shahabi Saeed , Sharifi-Rad Javad , Sheikhbahaei Sara , Varniab Zahra Shokri , Shorofi Seyed Afshin , Soodejani Moslem Taheri , Tbakhi Abdelghani , Tehrani-Banihashemi Arash , Tahbaz Sahel Valadan , Jabbari Seyed Hossein Yahyazadeh , Yousefi Zabihollah , Zamanian Maryam , Zare Iman , Zarrintan Armin , Zoladl Mohammad , Naghavi Mohsen , Larijani Bagher , Farzadfar Farshad TITLE=Burden of tracheal, bronchus, and lung cancer in North Africa and Middle East countries, 1990 to 2019: Results from the GBD study 2019 JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2023 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1098218 DOI=10.3389/fonc.2022.1098218 ISSN=2234-943X ABSTRACT=Objective

To provide estimates on the regional and national burden of tracheal, bronchus, and lung (TBL) cancer and its attributable risk factors from 1990 to 2019 in the North Africa and Middle East (NAME) region.

Methods and materials

The Global Burden of Disease (GBD) 2019 data were used. Disability-adjusted life years (DALYs), death, incidence, and prevalence rates were categorized by sex and age groups in the NAME region, in 21 countries, from 1990 to 2019. Decomposition analysis was performed to calculate the proportion of responsible factors in the emergence of new cases. Data are presented as point estimates with their 95% uncertainty intervals (UIs).

Results

In the NAME region, TBL cancer caused 15,396 and 57,114 deaths in women and men, respectively, in 2019. The age-standardized incidence rate (ASIR) increased by 0.7% (95% UI -20.6 to 24.1) and reached 16.8 per 100,000 (14.9 to 19.0) in 2019. All the age-standardized indices had a decreasing trend in men and an increasing trend in women from 1990 to 2019. Turkey (34.9 per 100,000 [27.6 to 43.5]) and Sudan (8.0 per 100,000 [5.2 to 12.5]) had the highest and lowest age-standardized prevalence rates (ASPRs) in 2019, respectively. The highest and lowest absolute slopes of change in ASPR, from 1990 to 2019, were seen in Bahrain (-50.0% (-63.6 to -31.7)) and the United Arab Emirates (-1.2% (-34.1 to 53.8)), respectively. The number of deaths attributable to risk factors was 58,816 (51,709 to 67,323) in 2019 and increased by 136.5%. Decomposition analysis showed that population growth and age structure change positively contributed to new incident cases. More than 80% of DALYs could be decreased by controlling risk factors, particularly tobacco use.

Conclusion

The incidence, prevalence, and DALY rates of TBL cancer increased, and the death rate remained unchanged from 1990 to 2019. All the indices and contribution of risk factors decreased in men but increased in women. Tobacco is still the leading risk factor. Early diagnosis and tobacco cessation policies should be improved.