AUTHOR=Tan Lulu , Fu Daan , Liu Feng , Liu Jia , Zhang Yang , Li Xin , Gao Jinbo , Tao Kaixiong , Wang Guobin , Wang Lin , Wang Zheng 

TITLE=MXRA8 is an immune-relative prognostic biomarker associated with metastasis and CD8+ T cell infiltration in colorectal cancer

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1094612

DOI=10.3389/fonc.2022.1094612

ISSN=2234-943X

ABSTRACT=<sec><title>Background</title><p>Colorectal cancer (CRC) is the second most common cause of cancer-related deaths worldwide. Tumor metastasis and CD8<sup>+</sup> T cell infiltration play a crucial role in CRC patient survival. It is important to determine the etiology and mechanism of the malignant progression of CRC to develop more effective treatment strategies.</p></sec><sec><title>Methods</title><p>We conducted weighted gene co‐expression network analysis (WGCNA) to explore vital modules of tumor metastasis and CD8<sup>+</sup> T cell infiltration, then with hub gene selection and survival analysis. Multi-omics analysis is used to explore the expression pattern, immunity, and prognostic effect of MXRA8. The molecular and immune characteristics of MXRA8 are analyzed in independent cohorts, clinical specimens, and <italic>in vitro.</italic></p></sec><sec><title>Results</title><p>MXRA8 expression was strongly correlated with tumor malignancy, metastasis, recurrence, and immunosuppressive microenvironment. Furthermore, MXRA8 expression predicts poor prognosis and is an independent prognostic factor for OS in CRC.</p></sec><sec><title>Conclusion</title><p>MXRA8 may be a potential immunotherapeutic and prognostic biomarker for CRC.</p></sec>