AUTHOR=Xia Yifei , Duan Shao , Han Chaozhe , Jing Chengwei , Xiao Zunyu , Li Chao 

TITLE=Hypoxia-responsive nanomaterials for tumor imaging and therapy

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1089446

DOI=10.3389/fonc.2022.1089446

ISSN=2234-943X

ABSTRACT=<p>Hypoxia is an important component of tumor microenvironment and plays a pivotal role in cancer progression. With the distinctive physiochemical properties and biological effects, various nanoparticles targeting hypoxia had raised great interest in cancer imaging, drug delivery, and gene therapy during the last decade. In the current review, we provided a comprehensive view on the latest progress of novel stimuli-responsive nanomaterials targeting hypoxia-tumor microenvironment (TME), and their applications in cancer diagnosis and therapy. Future prospect and challenges of nanomaterials are also discussed.</p>