AUTHOR=Blum Veronika , Andrei Vanghelita , Ameline Baptiste , Hofer Silvia , Fuchs Bruno , Strobel Klaus , Allemann Anna , Bode Beata , Baumhoer Daniel TITLE=Metastatic mesenchymal chondrosarcoma showing a sustained response to cabozantinib: A case report JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1086677 DOI=10.3389/fonc.2022.1086677 ISSN=2234-943X ABSTRACT=

Mesenchymal chondrosarcoma is a rare and aggressive sarcoma subtype with high risk for distant metastases and poor prognosis. Currently NCCN- and ESMO-Guidelines recommend using Ewing sarcoma protocols as standard treatment. Nevertheless, in localized disease overall 5-year survival rates are below 50% whereas in metastatic spread median progression-free survival rates of only 5 months can be expected. Here we present a patient with metastatic osseous spread of mesenchymal chondrosarcoma that showed a sustained clinical improvement and a good partial response on imaging over a period of one year when treated with the multi-tyrosine kinase inhibitor cabozantinib. Although we cannot explain the exact mechanism underlying this treatment effect, tumors with similar genetic patterns might respond to the same therapy as well.