AUTHOR=Aaltonen Kristina , Radke Katarzyna , Adamska Aleksandra , Seger Alexandra , MaƱas Adriana , Bexell Daniel TITLE=Patient-derived models: Advanced tools for precision medicine in neuroblastoma JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2023 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1085270 DOI=10.3389/fonc.2022.1085270 ISSN=2234-943X ABSTRACT=
Neuroblastoma is a childhood cancer derived from the sympathetic nervous system. High-risk neuroblastoma patients have a poor overall survival and account for ~15% of childhood cancer deaths. There is thus a need for clinically relevant and authentic models of neuroblastoma that closely resemble the human disease to further interrogate underlying mechanisms and to develop novel therapeutic strategies. Here we review recent developments in patient-derived neuroblastoma xenograft models and