AUTHOR=Zhou Bin , Shi Linli , Jin Min , Cheng Mingxia , Yu Dandan , Zhao Lei , Zhang Jieying , Chang Yu , Zhang Tao , Liu Hongli 

TITLE=Caulobacter and Novosphingobium in tumor tissues are associated with colorectal cancer outcomes

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1078296

DOI=10.3389/fonc.2022.1078296

ISSN=2234-943X

ABSTRACT=Diversity and composition of the gut microbiome is associated with cancer patients outcomes including Colorectal cancer (CRC). A growing number of evidence indicates Fusobacterium nucleatum (Fn) in colorectal cancer tissue is associated with worse survival. However, few studies have further analyzed the differences in bacteria in tumor tissues of different patients depending on the survival time of CRC patients. Therefore, there is a need to further explore the bacterial differences in tumor tissues of patients with different prognosis and to identify key bacteria for analysis. Here we sought to compare the differences in tumor microbiome between patients with long-term survival (LS) longer than 3 years or 4 and 5 years and patients with short-term survival (SS) in the present study cohort. We found that there were significant differences in tumor microbiome between the LS and SS and two bacteria-Caulobacter, and Novosphingobium-that present in all of the three groups. Furthermore, by analyzing bacteria in different clinical features, we also found that lower levels of microbiome (Caulobacter and Novosphingobium) have long-term survival and modulating microbiome in tumor tissue may provide an alternative way to predict the prognosis of colorectal cancer patients.