AUTHOR=Solár Peter , Mackerle Zdenek , Hendrych Michal , Pospisil Petr , Lakomy Radek , Valekova Hana , Hermanova Marketa , Jancalek Radim TITLE=Prolonged survival in patients with local chronic infection after high-grade glioma treatment: Two case reports JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1073036 DOI=10.3389/fonc.2022.1073036 ISSN=2234-943X ABSTRACT=

High-grade gliomas are primary brain tumors with poor prognosis, despite surgical treatment followed by radiotherapy and concomitant chemotherapy. We present two cases of long-term survival in patients treated for high-grade glioma and concomitant prolonged bacterial wound infection. The first patient treated for glioblastoma IDH-wildtype had been without disease progression for 61 months from the first resected recurrence. Despite incomplete chemotherapy-induced myelosuppression in the second patient with anaplastic astrocytoma IDH-mutant, she died without disease relapse after 14 years from the diagnosis due to other comorbidities. We assume that the documented prolonged survival could be related to the bacterial infection.