AUTHOR=Song Jiaxun , Yuan Xiaofeng , Piao Lianhua , Wang Jiawen , Wang Pu , Zhuang Ming , Liu Jie , Liu Zhiwei TITLE=Cellular functions and molecular mechanisms of ubiquitination in osteosarcoma JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1072701 DOI=10.3389/fonc.2022.1072701 ISSN=2234-943X ABSTRACT=

Although some advances have been made in the treatment of osteosarcoma in recent years, surgical resection remains the mainstream treatment. Initial and early diagnosis of osteosarcoma could be very difficult to achieve due to the insufficient sensitivity for the means of examination. The distal metastasis of osteosarcoma also predicts the poor prognosis of osteosarcoma. In order to solve this series of problems, people begin to discover a new method of diagnosing and treating osteosarcoma. Ubiquitination, as an emerging posttranslational modification, has been shown to be closely related to osteosarcoma in studies over the past decades. In general, this review describes the cellular functions and molecular mechanisms of ubiquitination during the development of osteosarcoma.