AUTHOR=Rubiu Emanuele , La Corte Emanuele , Bonomo Giulio , Restelli Francesco , Falco Jacopo , Mazzapicchi Elio , Broggi Morgan , Schiariti Marco Paolo , Pollo Bianca , Pinzi Valentina , Bruzzone Maria Grazia , Di Meco Francesco , Acerbi Francesco , Ferroli Paolo TITLE=Diagnostic and surgical management of primary central nervous system angioleiomyoma: A case report and literature review JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1072270 DOI=10.3389/fonc.2022.1072270 ISSN=2234-943X ABSTRACT=

Angioleiomyoma (ALM) is a benign smooth muscle neoplasm that mainly occurs in lower extremities subcutaneous tissue and generally affects middle-aged adults. This tumor histotype may rarely localize intracranially, although only a few cases have been described in the literature. We report a case of intracranial ALM, whose differential diagnosis has been particularly challenging, and firstly provide a comprehensive radiological and intra-operative evaluation of a such rare entity. This represents also the first report of the use of intraoperative confocal microscopy in ALM and the first documented short-term recurrence. At this regard, a scoping literature review has been conducted with the aim of presenting the major clinical and diagnostic features along with the proposed therapeutic strategies.