AUTHOR=Pezzani Raffaele , Jiménez-Garcia Manuel , Capó Xavier , Sönmez Gürer Eda , Sharopov Farukh , Rachel Tchokouaha Yamthe Lauve , Ntieche Woutouoba David , Rescigno Antonio , Peddio Stefania , Zucca Paolo , Tsouh Fokou Patrick Valere , Martorell Miquel , Gulsunoglu-Konuskan Zehra , Ydyrys Alibek , Bekzat Tynybekov , Gulmira Tussupbekova , Hano Christophe , Sharifi-Rad Javad , Calina Daniela TITLE=Anticancer properties of bromelain: State-of-the-art and recent trends JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2023 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1068778 DOI=10.3389/fonc.2022.1068778 ISSN=2234-943X ABSTRACT=

Bromelain is a key enzyme found in pineapple (Ananas comosus (L.) Merr.); a proteolytic substance with multiple beneficial effects for human health such as anti-inflammatory, immunomodulatory, antioxidant and anticarcinogenic, traditionally used in many countries for its potential therapeutic value. The aim of this updated and comprehensive review focuses on the potential anticancer benefits of bromelain, analyzing the cytotoxic, apoptotic, necrotic, autophagic, immunomodulating, and anti-inflammatory effects in cancer cells and animal models. Detailed information about Bromelain and its anticancer effects at the cellular, molecular and signaling levels were collected from online databases such as PubMed/MedLine, TRIP database, GeenMedical, Scopus, Web of Science and Google Scholar. The results of the analyzed studies showed that Bromelain possesses corroborated pharmacological activities, such as anticancer, anti-edema, anti-inflammatory, anti-microbial, anti-coagulant, anti-osteoarthritis, anti-trauma pain, anti-diarrhea, wound repair. Nonetheless, bromelain clinical studies are scarce and still more research is needed to validate the scientific value of this enzyme in human cancer diseases.