AUTHOR=Budi Hendrik Setia , Younus Laith A. , Lafta Methaq Hadi , Parveen Sameena , Mohammad Hawraa Jabbar , Al-qaim Zahraa Haleem , Jawad Mohammed Abed , Parra Rosario Mireya Romero , Mustafa Yasser Fakri , Alhachami Firas Rahi , Karampoor Sajad , Mirzaei Rasoul TITLE=The role of miR-128 in cancer development, prevention, drug resistance, and immunotherapy JOURNAL=Frontiers in Oncology VOLUME=12 YEAR=2023 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1067974 DOI=10.3389/fonc.2022.1067974 ISSN=2234-943X ABSTRACT=

A growing body of evidence has revealed that microRNA (miRNA) expression is dysregulated in cancer, and they can act as either oncogenes or suppressors under certain conditions. Furthermore, some studies have discovered that miRNAs play a role in cancer cell drug resistance by targeting drug-resistance-related genes or influencing genes involved in cell proliferation, cell cycle, and apoptosis. In this regard, the abnormal expression of miRNA-128 (miR-128) has been found in various human malignancies, and its verified target genes are essential in cancer-related processes, including apoptosis, cell propagation, and differentiation. This review will discuss the functions and processes of miR-128 in multiple cancer types. Furthermore, the possible involvement of miR-128 in cancer drug resistance and tumor immunotherapeutic will be addressed.